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Pericentromere specific probes?

Matan Yadgar
in Genetics

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Hi all,



Im trying to do a FISH on DNA combing for pericentromeric regions.



As you may know, the human centromere is actually separated into two distinct regions: 1) centromeric region - which is involved in kinetochore binding 2) pericentromere region - a heterochromatic region which is involved in sister chromatid binding.



Im looking for pericentromere specific probes which do not overlap with any other region (centromeric or non centromeric).



Does anyone have a clue whether this kind of probes/BAC/HAC/anything else exist? if so - a link would be great!



Thank you!



Matan


Edited by Matan Yadgar

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