Matan Yadgar
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Hi all, Im trying to do a FISH on DNA combing for pericentromeric regions. As you may know, the human centromere is actually separated into two distinct regions: 1) centromeric region - which is involved in kinetochore binding 2) pericentromere region - a heterochromatic region which is involved in sister chromatid binding. Im looking for pericentromere specific probes which do not overlap with any other region (centromeric or non centromeric). Does anyone have a clue whether this kind of probes/BAC/HAC/anything else exist? if so - a link would be great! Thank you! Matan