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Co receptors


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I am a newbie here and I apologize if this topic has already been covered. I had a question regarding co receptors involved in viral infection. How can one determine if a coreceptors is involved? These coreceptors may not bind to the viral coat and so binding assays will not give a result. Tissue tropism of certain viruses may be due to such co receptors, especially in hepatitis viruses. Can anyone help me?

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