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How does Type 1 diabtes mellitus caused by autoimmune destruction?

scilearner
in Medical Science

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Hello everyone,

 

What I just read is for type 1 diabetes mellitus, it requires an environmental factor (eg virus) and genetic determinant that allows the B cells to be detected as non self. Now I'm not very familiar with autoimmune diseases. My question is why does a virus have to come and trigger the autoimmune destruction of B cells. If B cells are alreadly genetically non self, shouldn't the body start attacking them without a stimulus? Thank you :)

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