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detoxic LPS vs toxic LPS

globy123
in Microbiology and Immunology

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Hi. I was wondering what is the difference between detoxic LPS and toxic LPS (LPS=lipopolysacharide)?

  • 1 year later...

hi

 

As we known the most toxic part of LPS is Lipid A, to reduce the toxicity of lipid A, subjected to mild hydrolysis, by which it loses a phosphate group. On that way we have an adjuvant. Its safe and doing mild stimulation our immune system, this might be is used in vaccines.

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