hi...

 

i wanted to know whether it is possible to produce acacetin by chemical means, also how feasible is the process and how economical is it??

 

Am planning for a project and desperately need the information......

 

please help..........

 

 

Ive just had a quick look at the problem and this was just the first one i came up with. All the steps are a well known as are the starting materials so it shoud work ok then. The second step is a 6-endo0DIG cyclisation which might be a little slow but should be ok.

in that synth the grignard adds to the double bond.. but then why is it still there in the product shouldnt it be gone by that approach

Arrr yes very good point.... lol yep i forgot that you don't get the double bond back.....let me have a rethink!

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Draw the curly arrows from the deproataned amine. You'll find that meta is the only position it wont get into the nitro

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Sorry ignore that bit about curly arrows and nitro groups

Edited February 3, 201015 yr by Horza2002