about Amiloride Hydrochloride

Amiloride Hydrochloride is an antikaliuretic-diuretic agent, it is a pyrazine-carbonyl-guanidine that is unrelated chemically to other known antikaliuretic or diuretic agents. Amiloride HCl is indicated as adjunctive treatment with thiazide diuretics or other kaliureticdiuretic agents in congestive heart failure or hypertension to:

help restore normal serum potassium levels in patients who develop hypokalemia on the kaliuretic diuretic;prevent development of hypokalemia in patients who would be exposed to particular risk if hypokalemia were to develop, e.g., digitalized patients or patients with significant cardiac arrhythmias.

Amiloride HCl is not an aldosterone antagonist and its effects are seen even in the absence of aldosterone，Amiloride HCl is usually well tolerated and, except for hyperkalemia ，significant adverse effects have been reported infrequently.