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Synthesis Help

blazinfury
in Organic Chemistry

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I need to synthesize, Phensuximide. The molecule is attached below. I need to begin with a benzaldehyde. Any advice? Thanks.

synth.png

Found a decent (at first glance... I emphasise the brevity of my search here) looking paper on the synthesis of derivatives of your compound. The reference is Miller et al, J Am Chem Soc 1951, 73 (12), pp5608-5610.

 

If you're looking for a retrosynthetic analysis I can't help you - I'm rustier than I care to admit with some of this chemistry.

Big hint: start with a wittig reaction to make styrene. SN2 will be important later on. Think cyanide.

Edited by UC

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