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New method of making antisense oligonucleotides!

Protoman2050
in Biochemistry and Molecular Biology

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Here's a new way of making PNA antisense oligonucleotides: Make artificial tRNA synthetases --http://www.cnrs.fr/cw/en/pres/compress/EvolutionCodeGenetique.htm -- that attach to PNA nucleotides, such that the one that hooks up to "A" in the mRNA sequence will place "U" in the PNA sequence. Of course, you'd have to add the 3' and 5' UTRs after the fact --in the 3'...5' format, of course--, so you could prefab those PNA oligonucleotides, and splice them to the oligonucleotide. Automatic antisense oligonucleotide manufacturing!!!

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