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scikle cell anemia +thalassemia

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hello all,i dont know if this is the right place to ask this question but anyway i want to know if it is possible that a person would be affected by both scikle cell anemia and thalassemia at the same time,although they are both abnormality in hemoglobine beta ? >:D

Yes. It is usually the same gene that is affected but thalassemia eliminates or breaks or messes up one copy (many redundant mutation across this and possibly other proteins). The other copy could have the sickle cell mutation, which is only one nucleotide altering one amino acid. The rest of the beta hemoglobin is the same.

 

This would be hetrozygous sickle cell condition which isn't as bad. It is unlikely a copy of a gene would be effected with both of these conditions and I have no idea what effect it would have.

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