immortal Posted March 3, 2007 Share Posted March 3, 2007 Hi, can anyone tell me how nitric oxide[NO] causes programed cell death by blocking the FAS pathway. Link to comment Share on other sites More sharing options...
Hoose Posted March 23, 2007 Share Posted March 23, 2007 Can you be a little more specific because it really depends on which protein you are talking about (ie. nNos, eNos, iNos) that forms NO resulting in oxidative toxicity. I also don't think that FAS ligand and FAS intteraction is actually blocked by NO since both are trying to initiate programmed cell death (apoptosis). NO is harmful for the cell and its production results in intracellular degradation and FAS pathway recruits in death domains that initiate a nuclease that is able to enter the nucleus and cleave DNA. Link to comment Share on other sites More sharing options...
immortal Posted March 25, 2007 Author Share Posted March 25, 2007 I am talking about the enzyme casparase. Link to comment Share on other sites More sharing options...
immortal Posted March 27, 2007 Author Share Posted March 27, 2007 I apologise it is caspase not casparase. Link to comment Share on other sites More sharing options...
Hoose Posted March 28, 2007 Share Posted March 28, 2007 Well, I'm pretty sure FAS ligand downstream components a cleave procaspase 3 into caspase 3 which cleave ICAD into CAD, which enters the nucleus to chop up DNA, but I still don''t this NO blocks FAS pathway. Link to comment Share on other sites More sharing options...
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