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Nanomachine to cell transport?

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First of all, I want to know how the scientist distinguish whether a virus have injected the enzyme of their target into a cell. For instance Crispr, you only need one virus to deliver the package into the cell, not two, and definitely not more than that. So how does the scientists control such a mechanism in which the virus only deliver their cargo into the cell once?

Apart from this question I want to open more opportunities as to how nanomachines could act like cargo trucks for delivery within our body.

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