mrlucky0

My first post so please bear with me if my question is a bit unclear. My professor was lecturing about enzyme kinetics and I am a little unclear about the meaning of Km. Specifically, Km is supposed to measure how effectively the enzyme binds to substrate and is defined: km = ((K-1)+(K2)) / (K1) Where K-1 is the rate of the reverse reaction: ES--> E+S, K2 is the rate of the product forming reaction: ES-->P, and K1 is the rate forward reaction: E+S-->ES My question: is K2 dependent on K-1 and K1 or independent? If independent, it would seem that if K1 was very large (good enzyme-substrate binding), and K-1 small, K2 could either be very large or very small. Thus, we wouldn't really be able estimate the magnitude of Km. Alternatively my hunch is that the rates are dependent but can someone explain how this could be so?