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telomerasa

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  1. I know that the effects of glucagon are the opposite of those of insulin. My question is if insulin acts as an inhibitor of glucagon secretion, why doesn't it work the other way round? Yes,I know it sounds weird and somewhat illogical but it is true, you can look in any physiology text and you will find that glucagon stimulates insulin secretion. But my question is why???
  2. Hi everybody! Does anyone know why does glucagon stimulate pancreatic beta-cells to secrete insulin? I have searched many articles, but I haven't found an answer.... I know that beta-cells have glucagon membrane receptors and that they work activating cAMP production, but what is the physiological translation of this? Why is glucagon an insulin secretagogue? Isn't high blood glucose concentration enough stimuli? I hope that someone can help me with this...
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