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I've tried doing it through my college's library website. Due to horrible design, it doesn't work.

Reviews are hard to access since my home computer isn't suscribed to any journals. I do actually read these papers with a textbook next to me. Two, in fact. Janeway's Immunobiology and Lehninger's Principles of Biochemistry. They both help to some degree but there are still terms, like LAT-Y136F mice and the HY thing, that are really only practical experimental terms and don't come up much in theory [and therefore not in these textbooks]. I use google too before posting it here; I'm obviously not asking for you guys to do my homework for me. I figure that LAT is the mutation introduced, but what is a Y136F mouse Here's a download link - https://www.yousendit.com/download/T2pIMWZQcGtwcFh2Wmc9PQ Haha! I figured out what LATY136F mice are! They're mice that have a mutation at the 136th amino acid, which is normally a tyrosine (Y), in their LAT protein! I'm guessing the F means that the mutation changed Y136 to an F136. Y136 is a binding site for PLC-gamma Haha! I figured out what LATY136F mice are! They're mice that have a mutation at the 136th amino acid, which is normally a tyrosine (Y), in their LAT protein! I'm guessing the F means that the mutation changed Y136 to an F136. Y136 is a binding site for PLC-gamma

I'm taking my first graduate/phd level immunology course. My prof has made it a task to assign a recently published paper to the class to present every week. He basically just hands us the paper and it's up to us to understand it. I have a lot of trouble in understanding some of the terms that, only if heard by an immunologist, would instantly know what it's experimental purpose is. My prof is strongly advocating a hands off sort of learning so I thought maybe you guys might be willing to help me out. This is the paper we got for this week http://www.jimmunol.org/content/184/5/2476.abstract What are LATY163F mice? What experimental purpose do they usually serve in an immunology study? What is a HY transgenic TCR model? What is HY for that matter? What is it used for experimentally?