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chen

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Lepton

Lepton (1/13)

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  1. I preferably want a practical way to do this not a way that would work on paper. I tried to get a NH2 group on benzene first: ~Benzene + HNO3/H2SO4 ---> Benzene-NO2 ~convert that to an amine by hydrogenation H2/Pd But then I couldnt use a Friedel Craft Acylation to add an aldehyde to the ring because the aryl amine will react with the acyl chloride and make the reaction extremely slow: Benzene-NH2 + CHOCl ---> Benzene-NHCHO but on the other hand, that could be the protecting group to the amine. Is there any other way to add a carboxylic acid onto the benzene ring after that step? <BR class=last-child>any thought is highly appreciated. Thank you.
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