Jump to content

esona

New Members

  • Joined

  • Last visited

View Profile Find content

Everything posted by esona

  1. esona

    Purifying Fluorinated Alcohol via flash Chromatography

    esona posted a topic in Organic Chemistry
    Hi everyone, I'm working on the fluorination of sulfonamide-linked alcohols using reagents like DAST and Fluolead. My target product is the mono-fluorinated derivative (–CH₂F). smiles code: O=S(=O)(NCCCF)c2ccc(c1ccccc1)cc2 However, I also observe the trifluorinated byproduct (–CF₃). smiles code: O=S(=O)(NCCC(F)(F)F)c2ccc(c1ccccc1)cc2 I’ve been trying to separate the two using flash column chromatography on silica, but they are very close in polarity on TLC (Hexane/Ethyl Acetate) Has anyone had success separating –CH₂F vs. –CF₃ derivatives? Any tips on solvent systems or additives would be really appreciated! Thanks in advance!

Important Information

We have placed cookies on your device to help make this website better. You can adjust your cookie settings, otherwise we'll assume you're okay to continue.

Configure browser push notifications
Chrome (Android)
  1. Tap the lock icon next to the address bar.
  2. Tap Permissions → Notifications.
  3. Adjust your preference.
Chrome (Desktop)
  1. Click the padlock icon in the address bar.
  2. Select Site settings.
  3. Find Notifications and adjust your preference.