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Findmeahope

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    Medicine, stem cells, body contouring, plastic surgery, biology, making peoples lives better

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  1. It's really hard to find experts, I thought I could get some answers here. I have tried contacting a few doctors with no avail. From reading 'Ontogeny of the Pelvis' - it appears that the growth trajectory in which growth plates (specifically the pelvis ones) grow is dependent on the hormone profile. It makes sense to me at least. https://anatomypubs.onlinelibrary.wiley.com/doi/pdf/10.1002/ar.23541 If anyone here knows of someone I could get hold of I would really appreciate it. I heard about this too. I hope something comes out of this in the context of the thread. I don't know if it's even much of a stretch considering they do complete replacements of bones in certain situations.
  2. Oh, so you don’t think it would provide any remodelling the bone itself? Like if a male type pelvis had epiphyseal plates placed in the areas where the previous plates closed, with the right hormone profile surely it would encourage the female trajectory of growth?
  3. Sorry to bump this thread, but I would like to ask you for your thoughts on the matter, I found this site: https://www.mtfbiologics.org/our-products/detail/pelvic-graft a company that provides grafts, these also include epiphyseal plates, do you think if this plates were to be transplanted to another person they would still be able to provide growth? If a post puberty bone were to have an epiphyseal plate transplanted back, would the body do what it does usually during puberty, which is removing old bone and making new bone effectively giving the bone structure it’s new shape.
  4. Is there anything else I could possibly do? Should I try another email? I have only sent one which was two months ago.
  5. That is true... I do have a question though, do you know of any ways I might be able to contact the author of the study? I've tried emailing the university but to no luck, no response
  6. I understand the caution with identity and vanity, however, it is absolutely a fact that sometimes the bone structures in males and females can be really drastic that it would take reopening those growth plates. Not just that, but this could be used to help anyone with any kinds of medical conditions, such as if someone's growth plates are faulty or close prematurely. When it comes to experimentation on animals, there's ethics that are involved isn't there? You aren't allowed to preform experiments on animals unless it is painless and humane, and if it hurts them, you need to stop? I might be wrong on this. I think though it's pretty straight forward, I can't imagine you'd need to do too much heavy experimenting except for the regulating of hormones to encourage the regeneration of the growth plates.
  7. Hi all, I posted here a while ago on the topic of 'bone remodeling' specifically in relation to the pelvis. Many here disagreed with the premise to even begin with, others think it's too far off. My initial thought was that bones could be remodeled through cutting bone and carefully placing and removing bits and pieces to create the desired outcome. Cutting bone and replacing parts with stem cell-grown material is invasive to put it simply, and absolutely would require a large recovery time and risk assessment as well as research. However, while discussing this with others interested, a research article was found that documents the and I quote: "reappearance of growth plate." Two young patients in this study were of the age where the growth plates have closed, however, following a break in the ankles, there was a reappearance of the growth plate. Others have speculated that this could be a mixture of hormones that could influence the reappearance of the growth plates; hormones control osteoblasts and osteoclasts, between ossification and resorption. Controlling PTH and Vitamin D can influence presence and activation of osteoblasts and osteoclasts. Click here for the a summary of the study. And here for the full study paper. Through controlling of specific hormones, would it be viable to make precise cuts in the bone to lead to the reappearance of the growth plates? If this were to be successful, I imagine this would essentially aid in the changing of the pelvis almost completely, especially if it's a male pelvis to a female pelvis, though I'm not sure whether a female pelvis would or could go narrower through the use of growth plates. This would also help people who desire to be taller without going through the process of breaking the bones and stretching them slowly.
  8. Yes. They have been able to make "male eggs" and "female sperm". Though they have only been allowed to go through with mice. It would be good to see it done with human beings. The ethics behind this case aren't blurry, it's a case of people gatekeeping opportunities out of redundant fear.
  9. Ah I see, so that’s a plus! That means all that would need to be done is the reshaping of said bone to align with the pelvis structure. as for it being advisable… obviously probably not as I’ll showcase in the “presentation”, however, I do think it’s a start, what I’ll show is basically how one might go about remodelling a pelvis, this is ignoring all muscle attachments and ligaments. Later on I’ll focus on how to tackle the issue of ligaments specifically as well as muscles, though ligaments are the ones that I think will be the most tricky. From research I’ve done it seems this could very well be possible. Gotta start saving my sources so I can show you. Also sorry for late reply, lots of studying.
  10. I see, if donor bone is used wouldn’t the patient need to be on immune suppressants? Or would the body eventually replace the bone with its own cells? How long does the 3D printed bone last? I know titanium doesn’t last over a decade if I recall. im actually currently cooking something up, I think this’ll be able to show you how it could be done, so stay tuned!!
  11. Yeah China is not progressive at all. Maybe they could be convinced anyhow. I’ve been doing more studying recently and maybe it could be more possible with the combination of titanium or other safe material to hold the bones together while they heal. I don’t think it’s really that bad, calculations just need to be precise. Is there a material that binds with bone?
  12. I think there's some reason to experiment with something like this, not because it will have a large market, I think its market size will increase because many women are unhappy with their hip size, so the safer it becomes the more people will want it done. I think being able to do something like this would be revolutionary on it's own, and open up possibilities for people who have injuries, etc. I think the domino effect works both ways as we discussed before. Yeah, I really don't like that religion has dictated so much of what's possible. I actually want to try get in contact with the people who were involved in that procedure I sent you, the growing Vagina's in labs one. You wouldn't know anyway one might go about that, would you? I'm super interested to why this hasn't been attempted since and if so, why it hasn't been reported on. I have little hope for the USA, which is why places like Sweden and other progressed countries probably need to start kicking it up a notch in terms of medical quality and innovations, even if it means going to China to do that. I do think that since COVID there have been a lot of stagnation, however, I think the long term damages from COVID could be helped significantly through stem cell research, which as I said would come from such a breakthrough such as a remodeling a pelvis. I have attached some images, the pelvis doesn't seem to have such a drastic difference in terms of being sexed, so it would appear it would be straight forward to use bone lengthening methods to achieve this under the layers of muscles directly on the bone, however, there's one issue that makes this hard, ligaments. Ironically, there might actually be a way to achieve this a natural way; https://www.quora.com/Why-dont-cosmetic-surgeons-expand-the-pelvic-bone-on-MtF-transgender-people-as-an-alternative-to-silicone-implants If you take a read through some of the replies to this question, Kevin Stone makes a interesting point that I actually knew before , but not to this extent: " It probably means that hormones play a far greater role in pelvic geometry than they are given credit for. The most likely hormone to target is relaxin. Laxity in connective tissues between the components of the pelvis apparently plays a far greater role than is generally acknowledged. If that’s true, then it is also likely true that, even in the absence of relaxin supplementation to approach feminine levels, stretches that loosen those connective tissues may help. Another biomechanical difference between men and women that is often overlooked is the connective tissue web at the pelvic inlet (spanning the pubis and ischium) is markedly different, given that it is continuous in the male while it is discontinuous in the female, where the vaginal introitus compromises its continuity. This means that there would be less structural integrity to the female pelvic inlet, allowing it to open and biomechanically resulting in a wider flare to the ilia. If all of this is true, then the addition of relaxin to the hormonal regimen, addition of stretches to loosen pelvic joints, and the increased laxity afforded by sectioning of the pelvic inlet fascia in order to create a vaginal canal all have the potential to somewhat modify a natal male pelvis, even well beyond the age of 25, toward the classic female pelvic geometry. Again, recent studies now show pelvic geometry changing throughout life and doing so markedly post-menopause. " Even with the bone plates fusing, there's a change in the geometry of the pelvis. Another idea would be making it so the body remodels itself. Now this is obviously 200 years away but an interesting concept considering we already use stem cells naturally to replace our bones, so it could be possible if we figured out the instructions, we could modify it so that the body modifies it's bone (and organ if you wanna go far enough) structure. I'm weary of cutting through ligaments, since blood supply isn't great, but then again, if we can grow that tissue in a lab we bypass this issue once again, easily. Love to hear your thoughts, this is the first time I've had such proactive discussion around this, took me a while to find these forums.
  13. Not necessarily, as long as overall they do. All new procedures start off expensive, this is the nature of the economic system. An example of this is that many to most components within the smart phone were made by the government and funded by the government for university research, this only brought returns tens of years later. I'm actually currently doing economics and psychology at school which is why I can only really reply on weekends so I apologize for the response time. After that next year I'm going to do medical science as well as this is also an area I am passionate about. Also, I thought this would be interesting to show you. This is what we are capable of, amazing things to help people, we should absolutely do it. Oh, next reply I'll send you some threads I found on this topic, I think it might be of some interesting substance so stay tuned! Being on a science forum I hope you are all of the opinion that religious reasons to prevent human progress are empty arguments coming from a place of irrational emotion. The moral positions people hold on getting stem cells from embryos with peoples consent is similar to that of "anti-choice" people, thus they care about life until it is born, then as we can see with American conservatives, for all they care that baby can be born into a poor household and get abused. It's easier to advocate for a person who can't defend themselves and call you out on bullshit, which is what these "moral" and "religious" people usually do. Another words, we should do what's right, not what we think the little man in the sky says we should do. I do agree that Frankensteins exist, however this isn't really an argument against stem cells and organs, more so against anarcho-type systems where there is no regulation of what people can do. It's like advocating for a society without laws. Looking into the studies I can assure you most trans people undergo intense psycho therapy before surgeries and even GRS, which is far more "life changing" than what I am proposing. However I do get where you are coming from, as I think everyone is entitled to see a psychologist, especially in these situations. Oh it's okay, nevermind then I just am using the quote thingy at the top from now on. I've done research into this so I wouldn't be proposing it if I thought it wouldn't be beneficial. GRS is arguably far more intense than pelvic remodeling, yet vast majority of people that get it are actually okay with it. The problem arises when the medical techniques aren't honed. This is why we need more research into things that concern our fellow human beings, as this benefits everyone.
  14. I grew up in a family with neo nazi's, forgive me as I become suspicious sometimes. Though I agree it probably be nice to change sexualities. We can work on that when the technology gets there, right now I'd prefer to focus on something like this for this thread, I'll probably make another thread for changing sexuality tbh. I suck at the quote system so I'm just gonna reply to the ones with "" around them like last time. "It's being done every day. Unhappily, there is nothing I know of, so far, to speed bone healing. You're still looking at 6-8 weeks of healing after each surgical procedure. So, if the change can be affected with a minimum of interference with bone structure, and preferential lipo- or silicone treatments, hormone and exercise therapies, I would seriously consider those alternatives, or some combination." Stem cells, we just don't have enough research, obvious reasons. Governments have barred much access to stem cell research or have at least made it extremely difficult to study. "The even worse news is prices. In some provinces and states, some procedures are covered by public health insurance, but you have to study up on the fees and co-pay options before you decide on a regimen. The prices are truly daunting! " I just don't think this is something that should prevent research, prices are extremely high, this is an entirely different problem that's to do with the system. In the US, if you need treatment, chances are you just die. It's so expensive, this is America's problem, I doubt it'll be solved anytime soon though, they do love seeing their own die and then blaming it on the boogieman after all. "I would think three or four times, and consider all the other options, before jumping into pelvic reconstruction. The much better news is that health-care community takes this issue seriously and there is a ton of information as well as support. Here is a very mainstream overview of what's available. https://my.clevelandclinic.org/health/treatments/21526-gender-affirmation-confirmation-or-sex-reassignment-surgery. The link I gave you earlier is advertising a more extensive and expensive range of services." I understand, for now obviously it hasn't been looked into, but with the appropriate tools, it should be possible with nowhere near the danger that it would pose at the moment with no trials or research. Doing research within healing possibilities, stem cells is probably the way to go. And this as well. To name a few anyway. "I do get that. You can't be on discussion boards without encountering that granite wall of prejudice. Obviously, part of the solution is altering public perception - but that takes time, co-operation and media attention, and you can't wait another century for acceptance." It is definitely hard. But even with acceptance, having the body match as much as possible is beneficial overall all round. "I wonder why. How's it any skin off their... Do they feel you're deserting to the enemy - or what? Anyway, that's a whole 'nother can of Spaghetti-O's. " I don't understand? Do you mean penis'? I'm sorry I am unfamiliar with your use of words. "Yes, future technology, including stem cell remodelling, will make it much easier. But people who are desperately unhappy right now, that's little consolation. Such people need to access whatever help is at hand where they live.... plus perhaps consider the option of relocating to some place where they're more readily accepted or better served. But that's another avenue closed by this forever pandemic. " For sure, but in the meantime there's no harm in killing multiple birds with one stone though. Maybe in 500 years we could do it, I don't know though anytime soon. I think we'll be transplanting brains to bodies before we get to that point. Human's really are strange, I guess that's what makes us beautiful though.
  15. I am really sorry for late reply! I’ve had such a busy week!! It’s hard for me to respond to the entire quote at once so I’m going to take parts and put them in “” and then respond below. “I had assumed that from the start. We're talking about purely cosmetic, rather than functional changes. Fair enough - and a considerable alteration can be done now. How easy or difficult it is medically depends to a large extent on what the starting point is and what the aim is. Turning a male football player into a female fashion model is a formidable challenge, while turning a wimpy male stockbroker into a self-assured female stockbroker wouldn't be that hard, either surgically or psychologically. “ Like I said, no turning football players that are 6’4 into 5’5 fashion models, I don’t see this as purely cosmetic, it’s a different kind of cosmetic that’s needed for trans people, that’s the difference. Depending on how much the person has been affected by testosterone or estrogen, it shouldn’t be too difficult. It’s a matter of weighing out the bone structure. “As you say, emergent technology will make alterations more accessible and less arduous.” I hope so! “Still, my main concern is not with technique, which is already quite advanced, but with the patient's endurance. Every one of these procedures is lengthy and painful and requires a long recovery time. If you're going to have a new life as the person you've always felt you should be, I don't think you want to spend the best years of it in traction, isolation and physiotherapy.” I just don’t know if it would be near as bad as you suggest, sure, physio trips, sure, but I don’t think a surgery like this would be released to the public if these were the consequences, we need a way of speeding recovery. Which is where stem cells come in. “I would very strongly urge every prospective patient to do a cost-benefit analysis, and decide in very practical terms how much they actually need to change. There is a vast range and variety of both male and female body types: it shouldn't be that hard to find the right formula to go from the undesired to the desired type with a minimum of structural damage.” That’s true, but the point is to get the person as in line with that sex as possible, if we can do it, I think we should do what we can to do it. “You've mentioned that before. I don't know what will become possible, but I hope that, unless our society changes considerably in the meantime, this idea remains science fiction. Not because of what such technology would do for people who want a second chance to grow up the way they think nature should have let them grow up - they have all my sympathy. But for all the other people who would put that same capability to nefarious uses. All new technology has a dark side!” I understand. I just don’t think nefarious people should prevent the surgery for people that need it. I’m gonna tell you something that a lot of people usually don’t take into consideration. Trans people lag behind significantly compared to the rest of society and sexual minorities, this is due to a few reasons, first is stigma, second is the biggest one, passing. Trans people that don’t pass will struggle through life, relationships, sex, finding jobs, it becomes extremely difficult and sometimes impossible, in fact it’s dangerous. It’s even worse for trans people that are gay. Gay men particularly are very hostile towards trans men as it is. Being able to pass, is a must for this group, if we can do it, we should do it. I know you don’t want to see people suffer, you even said it, the way to do it is to make sure it’s done properly, every good thing is hijacked eventually, look at breast augmentations, but it shouldn’t stop us from trying to do what we can to help one another. Being able to get this kind of thing working along with the stem cells, would create a domino effect like you said happens with surgeries for injuries, just this time it would come from a surgery for a different kind of issue. Hope this made sense! A sex change isn’t changing someone’s sexuality though, even if they do become a woman or a man attracted to the opposite sex, and what about those who are attracted to the same sex? What you’re saying is to turn people straight, cool, then you should have no problem turning people gay then, I know a lot of women that wish they were lesbian, I know for a fact people would like to try that out. My main concern is that you spoke of only turning the said people straight, in which case I’m wondering if you’d want the same for people who want to be gay. If they can do it, I have no objection. It just shouldn’t be forced. And at that point I’d expect there not to be a societal expectation to wipe out lgbt people from existence. exactly! I agree, no one thought a pigs heart could work for us, just like no one thinks what I’m talking about will be done, but I know it will, I’m just speculating how so it could be. If we can do good, we should.
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