We don't use them for the qPCR reaction itself. We use them for RNA extraction and various reagent storage purposes. The plates as a whole have never been an issue, just a particular lot.
Our lab is experiencing a major issue with PCR results. We switched to a new lot of 96-well plates and suddenly started seeing rampant false signals causing QC failures. The specific product in question is the Agilent brand: Storage/reaction microplate, 96-well, polypropylene, 1 mL/round well, round bottoms, 32 mm height, irradiated. Part Number: 204357-100. Looking to see if any other lab out there is or has experienced a similar problem, especially specifically with this equipment.