Biochemstudneedshelp

I got the problem solved, its based upon rate laws.

No we have to integrate the equation d[ES]/dt = k1[E] - k-1[ES] - k2[ES] which would have been equal to zero if in steady state approx but in this case there’s no assumptions made whatsoever so the only way to do this is interagency this equation to maybe isolate ES. And I’m having trouble with that......

I know how to derive it with the steady state assumptions but I do not know how to approach this question without steady state assumptions (when formation and dissociation of [ES] intermediate is no longer equal to 0 anymore). I can do simple derivations but I’m not too strong in math so if anyone could guide me through, I’d very much appreciate the intellectual help. Thanks. equation: [E] + (k-1)<—>(k1) [ES] —>(k2) [E] + [P]