Which are the substances which make a person extremely depressed? These types of substances are used in poisoning a person. The strongest feeling that the effected person has that he becomes extremely "CALM"? These types of substances make a person "DISABLED" to do the anger; he becomes very peaceful. In this type of depression-cum-madness the main point is this that the person becomes peaceful, does not do the anger no matter whatever happens. He becomes weak, extremely slow, angerless, calm, speaks extremely less and stands or walk very less, does useless sedentary works, like watching tv in which he does not have to put an effort. The second strongest thing that he feels besides becoming extremely "PEACEFUL" that he starts hating going to work(professional work).