Jump to content

mike888

Members
  • Posts

    2
  • Joined

  • Last visited

mike888's Achievements

Lepton

Lepton (1/13)

0

Reputation

  1. thank you Bad for the reply. I have already tried DCC/DMAP in Ch2Cl2. I am still trying to find out if I succeeded or not. I am trying to make an ester from Retinoic acid with 3,5-Di-tert-butyl-4-hydroxy-benzyl alcohol (BHT-OH). Retinoic acid is notorious in flipping around its double bound and giving up isomers. at this stage I am more interested to put A+B together and get the ester. with steglich reaction I easily get the retinoic acid react with DCC, but it seems reaction does not give the ester I am looking for. stirring the mixture overnight at RT with drying tube attached produced two compounds along with starting material. one seems to be retinoic-DMAP, the other unknown. I am monitoring the reaction using HPLC and soon I will switch to LC/MS to figure out what is going on here many thanks for your reply mike
  2. Hi I am trying to make an ester from primary alcohol and carboxylic acid that contain multiple double bonds. Fischer–Speier esterification is not working since the addition of sulfuric acid causes the acid to react with double bonds. appreciate any advise
×
×
  • Create New...

Important Information

We have placed cookies on your device to help make this website better. You can adjust your cookie settings, otherwise we'll assume you're okay to continue.