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techkasamba

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  1. I am a trainee in a company which is producing 2-chloro-4-amino sulfonamide.

     

    They start with meta chloro aniline & did chlorosulfonation with CSA (chlorosulfonic acid) followed by SOCl2 (Sulfonyl chloride) & then amination using ammonia.

     

    When I referred Vogel, I found that

     

    R-H + ClSO3H = R-HSO3 + HCl

    R-H + 2 ClSO3H = R-SO2Cl + HCl + H2SO4

     

    Where R - is aromatic benzene ring.

     

    Since Company is already using 8 times of theoretical value why they are using sulfonyl chloride.

     

    The product is formed like this

     

    R1-SO2Cl + NH3 = R1-SO2NH2 +HCl

     

    Where R1 - is meta chloro aniline radical kind of structure.

     

    Can anyone help me.

    Can I use any other starting material for this product

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