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techkasamba

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  1. Can I make Dimethyl formamide by following method? Dimethyl amine hydrochloride is distilled with sodium formate to give Dimethyl formamide. It is reported for acetamide in other website.
  2. I am a trainee in a company which is producing 2-chloro-4-amino sulfonamide. They start with meta chloro aniline & did chlorosulfonation with CSA (chlorosulfonic acid) followed by SOCl2 (Sulfonyl chloride) & then amination using ammonia. When I referred Vogel, I found that R-H + ClSO3H = R-HSO3 + HCl R-H + 2 ClSO3H = R-SO2Cl + HCl + H2SO4 Where R - is aromatic benzene ring. Since Company is already using 8 times of theoretical value why they are using sulfonyl chloride. The product is formed like this R1-SO2Cl + NH3 = R1-SO2NH2 +HCl Where R1 - is meta chloro aniline radical kind of structure. Can anyone help me. Can I use any other starting material for this product
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