oldsalt19

While I lack any specific recommendations, old beliefs that say you are born with your maximum life-long number of brain cells are being shown by good peer reviewed science to be wrong wrong wrong. I am 70 years old. You are the hope of people like me. go go go.

I do not accept that religion must be exclusive of science. Personally, for example, I believe Evolution to be one of God's cleverest inventions. I will admit that religious conservatives have a hard time with that one.

How about good common sense? I have seen current exam rooms of at least one orthopedic surgeon where post op exams were done in which there were no hand washing facilities.

Why do certain parts of a properly operating gasoline engine not overheat? The cooling system, usually a fluid , circulates thereby removing or adding heat as needed. Actually, brain tissue is quite metabolically active. Even the cooling evaporation of sweat must be fed by transport of blood.

I've already posted once elsewhere on the forum. I guess I should have posted here first.

I can be known as "Old Salt." For real. I'm 70, verbose, and retired from 36 years as a Public Health Microbiologist. I bought my first microscope at age 12 and I'm still at it. I have a passion in my retirement for rescuing and studying older collections of microslides that are otherwise headed for the dump. These are treasures because they are the best that have been saved by whom are usually recently deceased educators, pathologists, and the like. What a waste. I do no work on actual patients or generate any real time results. There are no real names or other meaningful personal data on these microslides.

Hi, all.

I am the newest of newbies here. I bought my first microscope when I was 12. Now I am 70, retired after 36 years of public health microbiology, and I'm still at it. I like to rescue and study very old collections of microslides on the way to the dump. These are treasures because they are the best that have been saved by recently deceased educators, pathologist, and the like. I do absolutely no work on actual patients or generate any actual real time results.

Now, My question: I have been studying a pathology slide labeled as a cross section of a villous colon polyp complete with carcinoma "in situ." Note in my attached photo that the malignancy has easily made it to the margins of the polyp (arrow.) So then, how is "in situ" defined in this situation? I'm thinking that in situ must depend on whether the cancer has spread all the way down the stalk and into the intestinal wall without reference to the horizontal margins of the polyp. To my admittedly ignorant brain, this begs the question, what if the polyp is bent over so that part of a horizontal margin touches part of the intestinal wall. Does this incidental contact provide a path for the cancer to escape the polyp or is the intestinal wall possess sufficient integrity to resist such an attack?