microbio_geek15

So, I know that B cells need T cell help for proper activation and isotope class switching. But, in some autoimmune diseases (such as Rheumatoid arthritis) antibodies are produced of the IgG isotope that are specific for DNA. DNA cannot be presented to MHCs on B cells, therefore it cannot be presented to T cells either. So how exactly would you get an auto immune response? Anyone have any ideas to explaining this phenomena? Any help/insight would be much appreciated