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neo007

DNA Types A, B & Z

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Can anyone tell me where the A-form and Z-form of DNA is found? I understand that the B form is found in normal human cells, but where do the other two come from and do/can they exist in human cells?

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The A-form of DNA exists under conditions of dehydration or high-salt concentrations.

 

The Z-form I believe exists only in the lab. In addition to these three there are also C, D, E, and P forms. All of these....if I am correct are found under laboratory conditions, only. I could be wrong about this, however.

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so, the B form could potentially "denature" into the A form under high salt concentrations or with dehydration?

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The A form of DNA is biologically relevant because it is the conformation taken by double stranded RNAs and DNA-RNA hybrids. Furthermore, some bacteria can convert their DNA from B-DNA to A-DNA when they form spores (Mohr, SC. et al. (1991) PNAS 88, 77-81). Supposedly, the DNA is more resistant to degradation in the A conformation than in the B conformation.

 

Z-DNA is primarily though to be an artifact of the laboratory and there is no evidence that it is biologically relevant.

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Are there any sites with info about A and Z form DNA in detail? I've tried searching on google, but can't seem to find anything

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i've come across the wikipedia one before, and yeah is rather basic, but the second link seems more useful and more to what i'm looking for

thanks!

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