Sometimes an antigen will bind to surface antibodies on the B cell, but it will not activate the B cell..why?

B cell activation requires two distinct signals, and results in B cell differentiation into memory B cells or plasma cells. and creative diagnostics company provides high quality antigens and antibodies. The first activation signal occurs upon antigen binding to B cell receptors (BCRs). Upon binding to the BCR, the antigen is internalized by receptor-mediated endocytosis, digested, and complexed with MHC II molecules on the B cell surface. The second activation signal occurs via either a thymus-dependent or a thymus-independent mechanism. Most B cell responses to antigen require the interaction of B cells with T helper cells