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Relaxation of smooth muscle by MLCP vs. Latch state

schafer
in Anatomy, Physiology and Neuroscience

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Hello,

From reading about smooth muscle relaxation, I understood that MLCP enzyme (myosin light chain phosphatase) dephosphorylates the myosin. This leads to relaxation because dephosphorylated myosin is unable to bind actin in smooth muscle cells.

However, some smooth muscle cells have 'latch state' where myosin heads remain attached to the actin even after dephosphorylation.

I don't really understand what causes the difference between the two cases. In one, dephos. causes relaxation while in the other it causes prolong binding. Anyone knows the explanation?

 

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