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Nondisjunction

blazinfury
in Genetics

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I am confused about nondisjunction and so I tried to draw it out but am not sure if it's correct. Please comment on the attached picture.

 

From what I read, NDJ occurs in both males and females, but does it occur predominantly more in one sex than the other? For instance with regards to Kleinfelter's Syndrome (XXY), which results from Meiosis I NDJ, does it occur more in females than in males?

 

Thanks.

post-10112-0-63734900-1358038528_thumb.png

The picture is correct, though the number of chromosomes is a little misleading. Clearer to draw the full amount of chromosomes from the start.

 

As for male vs female. Maternal age is a significant risk factor of birth defects/aneuploidy. The underlying cause has been investigated and weakened cohesion looks to be a significant contributor. Papers below provide decent evidence to support weakened cohesion being a contributing cause of aneuploidy.

 

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2939204/ - chiang et al. 2011

 

http://www.ncbi.nlm.nih.gov/pubmed/22823533 - Duncan et al. 2012

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