Hello!

 

 

I need a cyclization reaction which goes in acidic environment.

But that substance should not react in a basic environment.

 

 

Thanks in advance.

If I google for "cyclization reaction", I get the wikipedia page, which mentions a Lewis acid catalyzed reaction as its 1st example. Is that good enough?

 

Did you already try to search around? What did you find so far?

Unfortunately, the Lewis acid as a catalyst is not suitable.

I tried to find information on this issue, but found reactions required or Lewis acid or heat.

 

I think, it would be better if I tell you more about the problem.

 

 

I'm looking for the substance non-biological origin, that have a spiral form, and can also compresses and decompresses as spring.

 

Rings like a coumarin will open in a basic environment. They must to unclench my spring. I need some group that will form a cycle in acidic environment, but will not change in the basic environment.