Will non-autologous human serum activate lymphocytes?

Will the use of commercially available human serum cause an activation of lymphocytes isolated from human whole blood by Ficoll gradient centrifugation when used for the in vitro cultures?

The commercially available serum will not be used during the lymphocyte isolation but only later for the in vitro culture.

Here is more info on the human serum that I use for the lymphocyte cultures:

http://www.paa.com/cell_culture_products/sera/human_sera/human_serum_offtheclot.html (Cat. No. C15-020)

Of course, I can also use the autologous serum obtained from the whole blood but there are experimental reasons why this not possible for all my experimental set-ups.