budullewraagh Posted September 16, 2004 Share Posted September 16, 2004 anybody have an image of the 5HT1 receptor? i need to know the structure of it ASAP. if you find it, i would be most grateful. thank you. Link to comment Share on other sites More sharing options...
badchad Posted September 16, 2004 Share Posted September 16, 2004 does the subtype matter? Link to comment Share on other sites More sharing options...
budullewraagh Posted September 17, 2004 Author Share Posted September 17, 2004 what do you mean? Link to comment Share on other sites More sharing options...
badchad Posted September 17, 2004 Share Posted September 17, 2004 Just that the 5-HT1 receptor can be further classified into subtypes, which are the 5-HT1A, 5-HT1B, and 5-HT1D (there may be a few more). These are your typical 7 transmembrane spanning G-protein coupled receptors. I'm familiar with the 5-Ht1A subtype. The 5-HT1A receptor is classically coupled to an inhibition of adenylyl cycle and a decrease in cAMP. It's the serotonergic autoreceptor and is usually activated in response to high levels of 5-HT. I don't think the receptor's crytal structure has been determined yet, though I could be wrong. Thus, and 7 transmembrane spanning g-protein coupled receptor will look similar to it. I'll try and attach an image. Link to comment Share on other sites More sharing options...
budullewraagh Posted September 17, 2004 Author Share Posted September 17, 2004 thanks a bunch Link to comment Share on other sites More sharing options...
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