Chembio Posted March 24, 2010 Share Posted March 24, 2010 What is the significance of Indole ring structures in biological systems? Link to comment Share on other sites More sharing options...
Horza2002 Posted March 24, 2010 Share Posted March 24, 2010 It has a hydrogen (attatched to the nitrogen) capbable of forming hydrogen bonds. It also has a large pi-electron system that is capabable of undergoing pi-stacking. Link to comment Share on other sites More sharing options...
Chembio Posted March 26, 2010 Author Share Posted March 26, 2010 (edited) Hey thanx, those two factors may have an effect truly, since you can assume that they make stabilizing interactions in the biological systems, but what is the main role of this ring structure? Edited March 26, 2010 by Chembio Link to comment Share on other sites More sharing options...
Horza2002 Posted March 27, 2010 Share Posted March 27, 2010 The pi-stacking especially will help stabilise protein structures that contain several aromatic rings. The major contributing factor that holds DNA together is by pi-stacking of the aromatic bases (not the hydrogen bonds between strands). So any structure that contains an indole may help hold an enzyme in the correct shape. Link to comment Share on other sites More sharing options...
Chembio Posted March 28, 2010 Author Share Posted March 28, 2010 Thank you very much.. I'll go with that... Link to comment Share on other sites More sharing options...
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