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Indole

Chembio
in Organic Chemistry

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What is the significance of Indole ring structures in biological systems?:rolleyes:

It has a hydrogen (attatched to the nitrogen) capbable of forming hydrogen bonds. It also has a large pi-electron system that is capabable of undergoing pi-stacking.

  • Author

Hey thanx, those two factors may have an effect truly, since you can assume that they make stabilizing interactions in the biological systems, but what is the main role of this ring structure?:confused:

Edited by Chembio

The pi-stacking especially will help stabilise protein structures that contain several aromatic rings. The major contributing factor that holds DNA together is by pi-stacking of the aromatic bases (not the hydrogen bonds between strands). So any structure that contains an indole may help hold an enzyme in the correct shape.

  • Author

Thank you very much.. I'll go with that...

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