MHC, the peptide, and TcR. The trio.

[Apoptosis]

Hey guys, I just wanna clear something up.

 

1. MHC molecule (alpha and beta chains) are held together by non-covalent interactions.

 

2. Is the peptide held on the hypervariable region of the MHC molecule by non-covalent interactions as well?

 

3. when the TcR binds to the peptide on the MHC and to the MHC itself, are they also non-covalent interactions?

 

Thanks guys, I appreciate your input.

 

[dttom]

1) Yes, for class II MHC; and yes for class I MHC too if 'beta chain' means beta-microglobulin.

2) Yes.

3) Yes.