Jump to content

MHC, the peptide, and TcR. The trio.

Apoptosis
in Microbiology and Immunology

Featured Replies

Hey guys, I just wanna clear something up.

 

1. MHC molecule (alpha and beta chains) are held together by non-covalent interactions.

 

2. Is the peptide held on the hypervariable region of the MHC molecule by non-covalent interactions as well?

 

3. when the TcR binds to the peptide on the MHC and to the MHC itself, are they also non-covalent interactions?

 

Thanks guys, I appreciate your input.

 

:confused:

1) Yes, for class II MHC; and yes for class I MHC too if 'beta chain' means beta-microglobulin.

2) Yes.

3) Yes.

Archived

This topic is now archived and is closed to further replies.

Go to topic listing

Important Information

We have placed cookies on your device to help make this website better. You can adjust your cookie settings, otherwise we'll assume you're okay to continue.

Configure browser push notifications
Chrome (Android)
  1. Tap the lock icon next to the address bar.
  2. Tap Permissions → Notifications.
  3. Adjust your preference.
Chrome (Desktop)
  1. Click the padlock icon in the address bar.
  2. Select Site settings.
  3. Find Notifications and adjust your preference.