Proteus Posted October 9, 2009 Share Posted October 9, 2009 What are the most important differences between the two? Link to comment Share on other sites More sharing options...
GDG Posted October 9, 2009 Share Posted October 9, 2009 Wegener's granulomatosis is associated with the presence of classical anti-neutrophil cytoplasmic antibodies (c-ANCA, found scattered throughout the cytoplasm), while Churg-Strauss is associated with the presence of perinuclear or protoplasmic ANCA (p-ANCA, found mainly near the nuclear membrane). The antigen in WG is typically proteinase 3, while in CS it is usually myeloperoxidase. They otherwise have extremely similar symptoms. Link to comment Share on other sites More sharing options...
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