aznlouie408 Posted October 7, 2008 Share Posted October 7, 2008 Hi all, Can someone explain step 1 to 5 for me?? I'm trying to understand this reaction and I don't understand it. Appreciated if you guys could give me a detail explanation of each step. Please see below for the reaction diagram. Thanks a lot! -Louis Link to comment Share on other sites More sharing options...
Tartaglia Posted October 8, 2008 Share Posted October 8, 2008 Step I is a disguised aldol reaction Step II is a ketal formation via dehydration. The ketone effectively acts as a protecting group Step III is nucleophilic attack of (CH3)2S+-CH2- at the aldehyde, followed by ring closure to eliminate (CH3)2S and form the epoxide Step IV is nucleophilic attack of amine on the less hindered epoxide carbon, resulting in ring opening Step V is removal of the protecting ketone via acid hydrolysis Link to comment Share on other sites More sharing options...
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