chemdude Posted July 5, 2008 Share Posted July 5, 2008 Can someone please help me with the following question regarding the synthesis of sulfanilamide from aniline lab: Comment on the feasibility of the following alternative (see image below) as a synthetic route to sulfanilamide. How could this synthesis be modified to more successfully produce sulfanilamide? Link to comment Share on other sites More sharing options...
Tartaglia Posted July 5, 2008 Share Posted July 5, 2008 I would probably protect the -NH2 group with an acetyl group. Sulphonation I would probably carry out with ClSO3H (in xs) giving p-CH3C(O)NHC6H4SO2Cl. Treat with NH3 and hydrolyse to give sulphanilamide Link to comment Share on other sites More sharing options...
hermanntrude Posted July 5, 2008 Share Posted July 5, 2008 moved to homework help Link to comment Share on other sites More sharing options...
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