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Help with Lipoproteins

wiseowl_00
in Biochemistry and Molecular Biology

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I'm trying to get my head around lipoproteins and have hit a stumbling block.

 

From what I am reading 'The exclusive apolipoprotein of LDLs is apo-B-100' So I take this to mean that they lack apo-E, which would therefore mean that the LDL receptors in the liver cells (and others?) wouldn't recognise the LDL. I feel like a dog chasing its tail.

I'm also wondering what the mechanism is that determines if IDLs are taken up by the liver or continue to loose triacylglycerols (and apo-E to HDLs???) to become LDLs.

 

Any help would be appreciated

Thanks,

Al.

  • 3 weeks later...

In fact, the liver has receptors for apo-B-100 and for apo-E. Apo-E receptors are present only in the liver

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