Jump to content

half life

danzman
in Medical Science

Featured Replies

Hi, new to the forum.

I have a question for you pharmacological types out there…

When you use the term “half-life”, as it relates to an organisms ability to remove a chemical, does the given half-life incorporate all of the secondary metabolites associated with the chemical? As an example, the given half-life of morphine is 2-3 hours. Morphine is metabolized mostly in the liver by glucuronidation to various other morphine analogues (M3G, M6G…) Does this half life value incorporate the time needed to remove these chemical as well? Also, how does HL (half-life) relate to physiological activity? The HL for some benzodiazepines is in excess of 100 hours, yet their effects wear off in only a few hours. So by taking more of the drug one begins to saturate their system with inactive analogues. What is this potency rate called if not half-life?

 

thanks

Archived

This topic is now archived and is closed to further replies.

Go to topic listing

Important Information

We have placed cookies on your device to help make this website better. You can adjust your cookie settings, otherwise we'll assume you're okay to continue.

Configure browser push notifications
Chrome (Android)
  1. Tap the lock icon next to the address bar.
  2. Tap Permissions → Notifications.
  3. Adjust your preference.
Chrome (Desktop)
  1. Click the padlock icon in the address bar.
  2. Select Site settings.
  3. Find Notifications and adjust your preference.