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Linear Free Energy Relationships

Mercurial
in Applied Chemistry

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Ok, so Linear Free Energy Relationships (LFERs) are used to follow the substituent effects on the kinetics or Keq of various reactions. Everything is compared to benzoic acid and what not. Anyway, so what's the prediciting power? Is there a universal Hammett plot that provides predication for any reaction of say the same type (i.e. Sn2) Also, if anyone has any insight as to how LFERs are used to determine affects of mutations in enzyme catalytic sites, I would love to read that too. Thanks :D

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