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Crossing cre-loxp knockout with reporter strain

Syda
in Genetics

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I am learning about cre-loxp recently at this is all new to me. I want to have a mouse strain that will have a tissue specific knockout of a certain gene. Is there a way to introduce a reporter in that same tissue?

For example, if I have a liver specific cre and I want the liver tissue to express lacz after knocking out the mitochondrial transcription factor from liver cells with floxed strains, what should be my approach?

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