Biochem Impact on Collagen Question

[SJP]

Hello. What in our biochemistry impacts collagen?

After a testcular infection, there was a significant decrease in testicular size. Shortly thereafter and over time, there's been observed sinking of the eyes due to the decrease collagen around and especially under. Also, the skin overall. Correlation?

Everything I see online is just about artificially adressing the issue (i.e. injections), but what's out there to resolve the root cause from a biochemistry standpoint?

What's the difference in biochemistry when measuting people with puffy bags under eyes (high collagen) vs. those with sunken under-eye area (low collagen)? Any studies I can be directed to?

Regards.