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Plasma osmolality

pegasus10
in Anatomy, Physiology and Neuroscience

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Hello, the following equation is the short formula to calculate plasma osmolality (I found it on my physiology book as well as on Wikipedia):

Calculated osmolality = 2 [Na] + [Glucose] + [Urea]

My question is: why is the concentration of Na+ (sodium ions) multiplied by 2?

Thanks in advance!

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