Cornerstone Life Science Research Articles of last Decade or so

Hello everyone,

for a university course I am currently collecting research articles in the field of biomedicine/genetics/molecular biology. I am particularly interested in papers which have been published within the last 15 years or so and which represent cornerstones of the life sciences. The articles are thought to be presented by the participating students in a "journal club" format. I was already thinking of the Yamanaka/ipSCs paper from 2007; the brainbow mouse paper(Livet et al, 2007), the essential genes of a minimum bacterial cell and first "synthetic cell" by Craig Venter's people and more recently, the 2012 CRISPR paper from Doudna's and Charpentier's groups. Could you guys think of any more papers I could add to such a collection?

Any suggestion will be appreciated.

Best,

esather