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ISSAC NEWTON

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Posts posted by ISSAC NEWTON

  1. i am interested in discussing about the pros and cons of having a vesicle of ph sensitive polymer (with drug to be delivered inside it), inside a vesicle of thermosensitive polymer for drug delivery. This gives us dual control capabilities that is temperature and ph based trigger mechanism.things i need to know about this are

    1. is this method a novel approach for drug delivery, for a disease which needs a local site and ph change for drug release.

    2. the ph sensitive polymer works based on feedback approach like the release of drug is based on ph change in the system.external triggering is involved for temperature change.

    3. what are the difficulties in design of such drug delivery approach.

    4. can i use this method specifically for some disease preferably(like some particular cancer demanding temperature and ph conditions) ?

    thank you all.
  2. If you are looking at simple filters using either a capacitor in series with the load to allow high frequency signals to pass or in parallel with the load to shunt high frequencies you will always get phase shift. The amount of phase shift will change with frquency but will never be as great as 90 degrees. If you consider a capacitor in isolation, i.e theoretically in a circuit with no resistance then any sine wave voltage will produce a sine wave of current with the current waveform leading the voltage waveform by 90 degrees. It is similar to a pure inductor except the current waveform lags the voltage by 90 degrees. A memory aid is the word CIVIL which helps you to remember "For a capacitor current leads voltage, voltage leads current in an inductor". Using a cro to see current waveforms can be done by inserting a small resistor of known value (say 0.1 ohm) and looking at the voltage waveform across the resistor. Calculate current using Ohm's law. If the resistor is small compared to the reactance of the inductor it will have little effect on the circuit action.

     

    THANK YOU FOR YOUR REPLY.NOW TELL ME WILL THERE BE A PHASE SHIFT IN THE INPUT SINE WAVE IN A LOW AND HIGH PASS FILTER WHEN THE GAIN=1?I GOT NO PHASE SHIFT WHEN I SIMULATED IT(@ GAIN=1).IF NO SHIFT,WHY? I WOULD LIKE TO KNOW THE REASON BEHIND IT.PHYSICAL INTERPRETATIONS ARE WELCOME RATHER THAN MATHEMATICAL REASONING.THANK YOU.

  3. what happens to the phase of a sine wave when passed through a high pass filter circuit and a low pass filter circuit.does capacitor always produce a 90 degree phase shift for a sine wave at all frequencies.please tell me the response at different frequencies of signals.can we see the phase shift produced by an inductor to current in a cro , or only voltages can be seen in it? please comprehend.

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