aftp2020
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I found the answer, and it is no.
0
I found the answer, and it is no.
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Genetics Question: Plasma Isotype Reversion?
in Biology
Posted
It's my understanding that through the process of class switch recombination, loci fragments are lost in the plasma cell's genome. Does this mean that reversion to a prior isotype cannot be achieved and that isotype switching is always a linear progression within the differentiated cell?
"While class switch recombination is mostly a deletional process, rearranging a chromosome in "cis", it can also occur (in 10 to 20% of cases, depending upon the Ig class) as an inter-chromosomal translocation mixing immunoglobulin heavy chain genes from both alleles." (https://www.wikiwand.com/en/Immunoglobulin_class_switching)
I further understand that the deletional process utilizes NHEJ. Could this trans acting translocation accomplish restorative function of a prior isotype?
Thanks