ivanos

Thank you for help! Now it's clear. Here is a proposed synthetic route which I made. Is it correct to use TMS group in β-elimination to form the final α,β-unsaturated carbonyl? The problem is that my starting material will be 5-(trimethylsilyl)cyclohex-2-enone which isn't commercially available. I know that this compound could be synthesized from anisole but doesn't make it whole synthesis too complicated? I thought about using NBS to perform β-elimination, but the problem is the double bond in side chain. Do you have any other ideas about formation of α,β-unsaturated fragment?

I thought I could do LDA/2-iodopropane as a next step (through enolate form), but now I am confused.

Hello, I have a problem with retrosynthesis as shown on Fig. 1. I have to synthesize the product starting from cyclohexenone. I think first step in normal synthesis will be the Michael addition as shown on Fig. 2., but I have no idea about next steps. Do you have any advice?